Terrible calf pain running?

if i dont run, jump rope, muay thai, ect things that im on my toes for over a week, then im fine for my first run, but after that run, then it kills, and i cant run for another week. i dont know if its from cramps, or inflammation, but it kills.... i have inflammation in my forearm and it feels the same as in my calf, so im leaning more towards inflammation... all i know is that it kills, but i love running, so any help would be great, thanks everyone